Pharmacokinetics of levamisole in sheep
Bogan, J.A.; Marriner, S.E.; Galbraith, E.A.
Research in Veterinary Science 32(1): 124-126
1982
ISSN/ISBN: 0034-5288 PMID: 7089376 Document Number: 194964
Levamisole, at a dose rate of 7.5 mg/kg, produced mean peak plasma concentrations of 3.1, 0.7 and 0.8 microgram/ml in four sheep after administrations by the subcutaneous, oral and intraruminal routes respectively. The mean peak concentrations in abomasal fluid were 33, 164 and 21 micrograms/ml respectively. The bioavailability of levamisole to the systemic compartment was less after oral and intraruminal administration than after subcutaneous administration. In six sheep there were no significant differences in the plasma concentrations obtained after subcutaneous administration in the thoracic, neck or gluteal regions. Dividing the dose between five sites in the gluteal region produced higher peak plasma concentrations than when injected into a single site.