Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats
Brookman, S.; Kourounakis, P.
Arzneimittel-Forschung 32(10): 1298-1301
1982
ISSN/ISBN: 0004-4172 PMID: 6891231 Document Number: 194465
The influence of pregnenolone-16 alpha-carbonitrile (PCN) upon the biliary and urinary excretion of unchanged imipramine and some of its metabolites was investigated in female rats. The substrate and its metabolites were identified and quantified by thin-layer chromatography and/or gas-liquid chromatography. PCN augmented urinary excretion of desipramine and the imipramine- and desipramine-glucuronides. PCN pretreatment also diminished the urinary elimination of imipramine N-oxide whereas proadifen hydrochloride had an inverse effect, suggesting a shift in the metabolic pathways of imipramine. The biliary excretion of the imipramine and desipramine glucuronides was not significantly altered by PCN.