Urinary excretion of phenolic metabolites of N- (n-propyl) amphetamine in man
Coutts, R.T.; Dawson, G.W.
Research Communications in Chemical Pathology and Pharmacology 17(2): 349-352
1977
ISSN/ISBN: 0034-5164 PMID: 877419 Document Number: 118162
In vivo metabolism of (+)-N-(n-propyl)amphetamine (NPA) in man (2 subjects) produced, among other products, two conjugated phenolic metabolites which are identified as 1-(4-hydroxyphenyl)-2-(n-propylamino)propane and 1-(4-hydroxy-3-methoxyphenyl)-2-n-propylamino)propane. In a 24 hr urine sample (pH uncontrolled), 13.4% of the NPA administered was excreted as the former, and 3.5% as the latter metabolite.
Document emailed within 1 workday
Related Documents
Beckmann, H.; van Kammen, D.P.; Goodwin, F.K.; Murphy, D.L. 1976: Urinary excretion of 3-methoxy-4-hydroxyphenylglycol in depressed patients: modifications by amphetamine and lithium Biological Psychiatry 11(4): 377-387Yeh, S.Y.; Gorodetzky, C.W.; McQuinn, R.L. 1976: Urinary excretion of heroin and its metabolites in man Journal of Pharmacology and Experimental Therapeutics 196(2): 249-256
Ericsson, O.; Danielsson, B. 1977: Urinary excretion pattern of methaqualone metabolites in man Drug Metabolism and Disposition: the Biological Fate of Chemicals 5(6): 497-502
Raczyńska, B.; Litwin, E.; Lenartowska, I. 1970: Studies on the urinary excretion of metabolites of cozticostezoids in the developing infants Polski Tygodnik Lekarski 25(23): 852-855
Pirrelli, A.; Pieri, R.; Dolce, E. 1974: Changes induced with propranolol in the urinary excretion of catecholamines and adrenergic metabolites Bollettino della Societa Italiana di Biologia Sperimentale 50(21): 1797-1800
Chernov, A.Z.; Kushakov, V.I. 1970: Urinary excretion of hydrocortisone, cortisone and their metabolites in patients with congestive circulatory insufficiency Terapevticheskii Arkhiv 42(8): 85-87
Brookman, S.; Kourounakis, P. 1982: Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats Arzneimittel-Forschung 32(10): 1298-1301
Butrova, S.A. 1972: Effect of replacement therapy on the urinary excretion of testosterone and its basic metabolites, androsterone and etiocholanolone, in men with hypogonadism Problemy Endokrinologii 18(5): 24-27
Reddy, T.V.; Ramanathan, R.; Benjamin, T.; Grantham, P.H.; Weisburger, E.K. 1986: Effect of microsomal enzyme inducers on the urinary excretion pattern of mutagenic metabolites of the carcinogen 2,4-toluenediamine Journal of the National Cancer Institute 76(2): 291-297
Popa, M.; Stefănescu, A.M.; Dumitriu, L. 1986: Urinary excretion of catechol metabolites particularly MHPG in children. Relation to age, body mass indices and thyroid function Endocrinologie 24(3): 203-214
Minami, M.; Togashi, H.; Sano, M.; Yoshioka, M.; Saito, I.; Morii, K.; Tochihara, M.; Hirogami, M.; Nomura, A.; Saito, H. 1985: Effects of new antihypertensive agent, 2-[4-(n-butyryl)-homopiperazine-1-ul]-4-amino-6, 7-dimethoxy-quinazoline (E-643), on blood pressure, urinary sodium excretion and urinary norepinephrine excretion rate in stroke-prone, spontaneously hypertensive rats Hokkaido Journal of Medical Science 60(4): 536-543
Agnoli, G.C.; Borgatti, R.; Cacciari, M.; Dorigoni, S. 1985: Potassium balance, acute changes in diuresis and urinary excretion of arachidonic acid metabolites. I: Studies on normal potassium balance Bollettino della Societa Italiana di Biologia Sperimentale 61(7): 1021-1027
Pratt, J.H.; Luft, F.C. 1979: The effect of extremely high sodium intake on plasma renin activity, plasma aldosterone concentration, and urinary excretion of aldosterone metabolites Journal of Laboratory and Clinical Medicine 93(5): 724-729
Raig, P.; Beschorner, J.; Ammon, R. 1976: Comparative studies in vivo and in vitro on the formation of phenolic biphenyl metabolites in various animal species[ Arzneimittel-Forschung 26(12): 2178-2182
Ott, D.E. 1979: Mechanized system for liquid chromatographic determination of 4-nitrophenol and some other phenolic pesticide metabolites in urine Journal - Association of Official Analytical Chemists 62(1): 93-99
Liu, J.; Ye, H.; Lou, Y. 2005: Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells Die Pharmazie 60(2): 120-125
Meyer, E.M.; Lytle, L.D. 1978: Sex related differences in the physiological disposition of amphetamine and its metabolites in the rat Proceedings of the Western Pharmacology Society 21: 313-316
Jori, A.; Caccia, S. 1974: Distribution of amphetamine and its hydroxylated metabolites in various areas of the rat brain Journal of Pharmacy and Pharmacology 26(9): 746-748
Kolachana, P.; Subrahmanyam, V.V.; Meyer, K.B.; Zhang, L.; Smith, M.T. 1993: Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo Cancer Research 53(5): 1023-1026
Takahashi, K.; Shimamine, M.; Ono, M.; Kawasaki, Y.; Sekita, K.; Furuya, T. 1983: Microanalysis of amphetamines II. Detection of metabolites in the body fluids of the amphetamine-treated monkeys Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 101: 14-18