Dynamics of the change in the prostaglandin content of brain tissue in upper cervical sympathectomy and circulatory hypoxia
Govorova, L.V.; Kucherenko, A.G.; Markov, K.M.; Tashaev, S.S.; Teplov, S.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(4): 3-6
1982
ISSN/ISBN: 0365-9615 PMID: 7082797 Document Number: 194152
A study was made of the effect of cervical sympathectomy (SE) on the time course in the content of prostaglandins (PG) (E + A) and F2 alpha under normoxia and circulatory hypoxia. The sympathectomized rats manifested a biphasic change in the content of PG (E + A). The content of PG (E + A) rose by days 1 and 7. It returned to normal by day 14 and increased again by day 40 after SE. The content of PG F2 alpha drastically increased 7 days after SE and then returned to normal. Brain ischemia induced by bilateral ligation of the common carotid arteries led to an increase in the content of PG (E + A) and in that of PGF2 alpha, in particular. Preliminary SE resulted in the absence of differences in the content of PG (E + A) caused by brain ischemia. It is assumed that PGF2 is largely implicated in the regulation of the tone of the bran vessels and in the regulation of metabolism during ischemia with disordered sympathetic control.