Reflection of reserves of the brain energy mechanisms in cerebral blood flow dynamics in human under acute hypoxia
Burykh, É A.; Soroko, S.I.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 100(11): 1310-1323
2014
ISSN/ISBN: 0869-8139 PMID: 25665410 Document Number: 671478
Results of experimental researches of the cerebral blood flow (CBF) dynamics in human under acute hypoxia have been analyzed in the paper. It was found that changes of CBF under severe acute hypoxia are of nonlinear character and have several phases--the primary growth in the first minutes of hypoxia, relative stabilization and secondary growth. Secondary growth has no relation to changes of the hypoxemia level. It begins earlier under more severe hypoxia and in individuals with less resistance to oxygen deficit. Opposite to this, hypoxic training prolongs the time from the onset of hypoxia till the moment of the CBF secondary growth. The hypothesis was suggested that the CBF secondary growth reflects a phase of certain exhaustion of the brain's neuronal mitochondrial reserve capacity, which is accompanied by accumulation of vasoactive substances--precursors of ATP.