Cytoprotection by PGE2, atropine, pirenzepine and vagotomy in rats
Rovati, V.; Foschi, D.; Ferrante, F.; Del Soldato, P.; Daniotti, S.; Varin, L.
Scandinavian Journal of Gastroenterology. Suppl 72: 261-264
1982
ISSN/ISBN: 0085-5928 PMID: 6957994 Document Number: 194122
Gastric cytoprotective effects of vagotomy, PGE2 and antimuscarinic compounds (pirenzepine, atropine) were studied in the rat. Both pharmacological and surgical treatment prevented the gastric damage induced by intragastric administration of acetylsalicylic acid plus hydrochloric acid. The mechanisms of action are discussed.
Document emailed within 1 workday
Related Documents
Chariot, J.; De la Tour, J.; Vaille, C.; Rozé, C. 1987: Comparative effects of pirenzepine and atropine on pancreatic secretion in conscious rats Archives Internationales de Pharmacodynamie et de Therapie 285(1): 158-165Hirschowitz, B.I.; Fong, J.; Molina, E. 1983: Effects of pirenzepine and atropine on vagal and cholinergic gastric secretion and gastrin release and on heart rate in the dog Journal of Pharmacology and Experimental Therapeutics 225(2): 263-268
Konturek, S.J.; Obtulowicz, W.; Kwiecień, N.; Dobrzańska, M.; Swierczek, J.; Kopp, B.; Olesky, J. 1980: Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer Scandinavian Journal of Gastroenterology. Suppl 66: 63-69
Tanaka, H. 1986: Gastric cytoprotection of aceglutamide aluminium in rats Arzneimittel-Forschung 36(10): 1485-1489
Wang, J.-M.; Wang, H.; Xu, L.-N.; Zou, S.-Q. 2005: Hepatic injury in rats with obstructive jaundice: roles of the protein kinase C signal pathway and cytoprotection of fructose Hepatobiliary and Pancreatic Diseases International: Hbpd Int 4(4): 577-581
Kobayashi, S.; Kyui, S.; Yoshida, T.; Nagakura, A.; Oiwa, Y.; Matsumura, R.; Kohei, H. 1981: Absorption, distribution and excretion of 14C-pirenzepine in rats. Accumulation characteristics after multiple dose regimen Arzneimittel-Forschung 31(4): 679-690
Okabe, S.; Tabata, K.; Kawakami, M. 1982: Effects of prolonged treatment of pirenzepine 2HCl on gastric secretion and plasma gastrin levels in rats Arzneimittel-Forschung 32(6): 664-668
Herman, Z.S.; Słomińska-Zurek, J. 1981: Enhanced responses to muscarine in rats treated chronically with atropine Polish Journal of Pharmacology and Pharmacy 33(5): 481-484
Ittichaikulthol, W.; Pisitsak, C.; Wirachpisit, N.; Piathong, P.; Suyawet, R.; Komonhirun, R. 2014: A comparison of the combination of atropine and glycopyrrolate with atropine alone for the reversal of muscle relaxant Journal of the Medical Association of Thailand 97(7): 705-709
Bugajski, J.; Hano, J.; Wantuch, C. 1973: Effect of serotonin and atropine on reserpine-induced gastric secretion in rats Polish Journal of Pharmacology and Pharmacy 25(6): 525-535
Obuchowicz, E.; Zieliński, M.; Herman, Z. 1982: The effects of mecholyl and atropine on the muscarinic receptors in rat small intestine after long-term atropine administration in vivo Acta Physiologica Polonica 33(5-6): 597-600
Gengin, M.T.; Solov'ev, V.B.; Smetanin, V.A.; Pazialova, A.A.; Simkina, O.V.; Konovalov, A.N.; Kuzichkin, D.S.; Shashkina, N.K.; Gengina, N.M.; Subbotina, K.B. 2005: Atropine effect on activity of angiotensin-converting enzyme and carboxypeptidase n in the serum of rats Ukrains'kyi Biokhimichnyi Zhurnal 77(6): 94-96
Tanasijević, D. 1986: The effect of atropine, Hi-6 and diazepam on the levels and metabolism of monoamines in the brain of rats poisoned with VX Godisnjak Vojnomedicinske Akademije 28: 50-55
Villavicencio, J.; Domínguez, R. 1988: Different ovulatory response to copulatory stimulus in rats treated with reserpine or atropine on diestrus day one Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 40(3): 231-235
Miyasaka, K.; Tateishi, K.; Masuda, M.; Jimi, A.; Funakoshi, A. 1999: Atropine-resistant secretion of a putative luminal CCK-releasing peptide in conscious rats American Journal of Physiology 276(1): G287-G292
Deng, X.F.; Mulay, S.; Chemtob, S.; Varma, D.R. 1997: Mechanisms of the atrium-specific positive inotropic activities of quinidine- and atropine-like agents in rats Journal of Pharmacology and Experimental Therapeutics 281(1): 322-329
Maouyo, D.; Guan, D.; Rivard, N.; Adelson, J.W.; Morisset, J. 1995: Stability of circadian and minor cycles of exocrine pancreatic secretion in atropine- and MK-329-infused rats American Journal of Physiology 268(2 Pt 1): G251-G259
Schumpelick, V.; Kauffmann-Mackh, G. 1974: Vagotomy in the prevention of ulcer after portocaval anastomosis in rats Deutsche Medizinische Wochenschrift 99(38): 1872; 77
Beró, T.; Németh, A.; Mózsik, G.; Jávor, T. 1984: The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats Acta Physiologica Hungarica 64(3-4): 343-347
Tashkin, D.P.; Katz, R.M.; Kerschnar, H.; Rachelefsky, G.S.; Siegel, S.C. 1977: Comparison of aerosolized atropine, isoproterenol, atropine plus isoproterenol, disodium cromoglycate and placebo in the prevention of exercise-induced asthma Annals of Allergy 39(5): 311-318