Occlusion of the pancreatic ducts with "Ethibloc" injections. Experimental study in the dog
Alexiou, D.; Kauffmann, J.P.; Arzoglou, P.L.; Warter, A.; Ferard, G.; Karayannacos, P.; Skalkeas, G.R.; Hollender, L.F.
Journal de Chirurgie 119(10): 597-602
1982
ISSN/ISBN: 0021-7697 PMID: 7174753 Document Number: 194111
"Ethibloc" is a zeine-alcohol suspension which polymerizes in an aqueous medium after approximately 15 minutes. The product was injected in the pancreatic duct of 20 dogs. The procedure was free from complications, apart from the development of edematous pancreatitis without clinical manifestations. Healthy pancreases were transformed into fibrous organs within ten days or so, as is found in advanced stages of chronic pancreatitis. No effect occurred on the islets of Langerhans and a diabetes of the experimental type did'nt develop. "Ethibloc" would therefore appear to be of value in humans for the treatment of chronic pancreatitis, in order to reduce the period for transformation of the lesions without increasing the incidence of complications, and also for pancreatic fistulae of various origins, as a result of the rapid sclerosis of exocrine tissue that it provokes.