Experimental study on the occlusion of arterial blood flow by the implantation of nitinol alloy stents

Huang, J.; Ma, G.S.; Wang, J.L.; Ma, W.Z.; Wang, S.D.; Wu, X.Z.

Chinese Medical Journal 107(7): 512-514

1994


ISSN/ISBN: 0366-6999
PMID: 7956498
Document Number: 431786
To evaluate the occlusion of arteries, 6 conic intravascular endoprosthetic stents of titanium-nickel alloy were implanted transluminally to the right external iliac arteries in 2 normal dogs and 4 normal pigs. The stent was characterized by ductility below 313 K (40 degrees C) and restoration memory-shape between 313-319 K. The diameter of the large end of conic stent was 4.0 mm (dog) and 4.5 mm(pig). The topographic anatomy showed that the external iliac artery was near complete occlusion, with a very small residual lumen (about 1 mm in diameter) in dogs at 6 months, with complete occlusion in pigs at 8 months. The histopathological examination indicated that the arterial intima of the upper branch from the stented site was smooth, and that neither inflammatory cell infiltration nor foreign giant cell reaction was found. The newly formed granulation tissue inside the stent came from emboli organization. These results suggest that the shape-memory alloy stent has good biocompatibility and the conic intravascular endoprosthetic stent might completely occlude arterial blood flow.

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