Physiological approaches to the problem of inadequate responses of the kidney to hormones and diuretics
Natochin YuV; Merzon, A.K.; Ermakova, I.P.; Pinegin, L.E.; Tibekina, L.M.
Human Physiology 8(4): 280-287
1982
ISSN/ISBN: 0362-1197 PMID: 6764452 Document Number: 193575
A variety of experiments on renal responses in humans were conducted. Administration of deoxycorticosterone acetate to healthy subjects resulted in the development of renal insensitivity to their Na+ retaining action, while the renal response persisted for a long time in patients with chronic heart failure. The hypocalcemic action of bovine calcitonin decreased in cases of progressive heart failure. The areactivity to endogenous parathyroid hormone following a kidney allotransplant affected individual target organs selectively. The natriuretic response of the kidneys to furosemide was more marked in the neurovascular form of the hypothalamic syndrome than in patients with hypothalamic obesity. The different responses to hormones and diuretics are evidently the result of differences in the condition of effector organ cells as well as endocrine changes in the body.