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Grass sickness of horses: changes in the regulatory peptide system of the bowel

Hodson, N.; Edwards, G.B.; Barnett, S.W.; Bishop, A.E.; Cole, G.A.; Probert, L.; Bloom, S.R.; Polak, J.M.

Veterinary Record 110(12): 276

1982

ISSN/ISBN: 0042-4900
PMID: 7080418
Document Number: 193254
In the intestines of five horses with grass sickness there were fewer nerve fibres which stained for vasoactive intestinal polypeptide, substance P and encephalin. The mucosa was poor in cells containing enteroglucagon and somatostatin. Electron microscopy revealed extensive degeneration of intestinal nerve fibres. P-type fibres had undergone extensive degranulation with the formation of numerous vacuoles.

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