Chemotherapeutic activity of 2-chloroethylnitrosocarbamoyl derivatives of amino acids in a transplanted rat leukemia (L 5222)
Zeller, W.J.; Berger, M.; Eisenbrand, G.; Tang, W.; Schmähl, D.
Arzneimittel-Forschung 32(5): 484-486
1982
ISSN/ISBN: 0004-4172 PMID: 7201823 Document Number: 193173
The therapeutic activity of a single-dose treatment with 14 2-chloroethylnitrosocarbamoyl derivatives of amino acids (CNU-analogs) in L 5222 rat leukemia is presented. Compounds under study included free carboxylic acids, a methylester, a toluidide, four glucosamides and one derivative of a dipeptide. All substances proved to be active effecting at least an increase in life span of greater than or equal to 120% compared with untreated controls at the optimal dose; 2 compounds effected isolated cures (90-day survivors). Compared with previous data obtained with established and new nitrosoureas under the same conditions, the effectivity of the compounds presented here should be classified, however, only as moderate.