Formation of aberrant polyploid hepatocytes in exposure to the alkylating preparation dipin and to stimulation of proliferation
Uryvaeva, I.V.; Faktor, V.M.
Tsitologiia 24(8): 911-917
1982
ISSN/ISBN: 0041-3771 PMID: 7135484 Document Number: 192684
One month after the treatment of mice with the alkylating drug Dipin followed by partial hepatectomy 4.7--35.1% of hepatocytes with micronuclei and nuclear bridges in liver were registered. The ploidy level sharply increased. Aberrant cells were the most polyploid ones (16c, 32c). The DNA-fuchsin content in these aberrant polypolid cells decreased by 10--15% due to degrading and non-replication of DNA in the micronuclei.