C2 deficient systemic lupus erythematosus: its association with anti-Ro (SSA) antibodies
Vandersteen, P.R.; Provost, T.T.; Jordon, R.E.; McDuffie, F.C.
Archives of Dermatology 118(8): 584-587
1982
ISSN/ISBN: 0003-987X PMID: 6980631 Document Number: 192236
C2 deficiency is the most common complement component deficiency. While individuals with C2 deficiency may be completely normal, a lupus erythematosus-like disease process has developed in some. A 28-year-old woman had a chronic photodermatitis, arthralgias, and mesangial lupus nephritis, She has C2 deficiency associated with an HLA-Dw2 transplantation antigen. Her serum has shown antibodies to the macromolecule Ro (the A antigen in Sjögren's syndrome), while failing to demonstrate antinuclear antibodies in routine laboratory determinations.
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