Prevention of doxorubicin-induced skin ulcers in the rat and pig with dimethyl sulfoxide (DMSO)
Desai, M.H.; Teres, D.
Cancer Treatment Reports 66(6): 1371-1374
1982
ISSN/ISBN: 0361-5960 PMID: 7083241 Document Number: 191438
Ten potential agents were tested in the Sprague-Dawley rat, using the method of Rudolph et al., which produces skin ulcers with 0.4 mg of doxorubicin intradermally. One antidote, dimethyl sulfoxide (100%, 0.6 ml for 7 days), prevented ulcer formation at the local site and at the doxorubicin control injection site. Similar ulcers were produced in the Yorkshire pig with 2.0 mg of intradermal doxorubicin injection. These ulcers were prevented at local and distant control sites with dimethyl sulfoxide given for 7 days.