Lymphocyte blastogenesis in dogs with lymphosarcoma
Calvert, C.A.; Dawe, D.; Leifer, C.E.; Brown, J.
American Journal of Veterinary Research 43(1): 94-101
1982
ISSN/ISBN: 0002-9645 PMID: 6896408 Document Number: 190437
Mitogen-stimulated lymphocyte blastogenesis was evaluated, using lymphocytes from 37 dogs with multicentric lymphosarcoma. The majority of the test results was within a normal range, even for those dogs with more advanced disease. However, depressed lymphocyte blastogenesis, when present, almost always occurred in lymphocytes from dogs with clinical stage IV-B and V-B disease. Dogs weighing greater than 25 kg had a significantly (P = 0.04) higher occurrence of clinical stage IV or V disease as compared with dogs weighing less than 15 kg. Dogs with diffuse lymphocytic well-differentiated lymphoma were statistically more likely to be designated clinical stage III at the time of diagnosis, as compared with dogs with diffuse lymphocytic poorly differentiated lymphoma.