Raised endogenous monoamine oxidase inhibitor output in postwithdrawal alcoholics: effects of L-dopa and ethanol
Bhattacharya, S.K.; Glover, V.; Sandler, M.; Clow, A.; Topham, A.; Bernadt, M.; Murray, R.
Biological Psychiatry 17(7): 829-836
1982
ISSN/ISBN: 0006-3223 PMID: 7115834 Document Number: 190237
Urinary output of endogenous monoamine oxidase inhibitor was significantly greater in a group of postwithdrawal alcoholics than in controls. An oral dose of 0.5 g of L-dopa reduced output to control values in the alcoholics, but in the controls themselves output was unaffected. A similar excretion pattern to unextracted samples was observed in ethyl acetate extracts of these urine samples, acidified to pH 1. In a second group of postwithdrawal alcoholics, where the L-dopa effect was confirmed, ethanol administration brought about a small but not significant reduction in inhibitor output.