Selectivity of an indole-hydrazide derivative as inhibitor of mouse brain type a monoamine oxidase
Gurpegui, M.; Monge, A.; Fuentes, J.A.
Arzneimittel-Forschung 31(10): 1710-1712
1981
ISSN/ISBN: 0004-4172 PMID: 7198447 Document Number: 176767
The first indole-hydrazide, 1-[2,-(3-methyl)-5-benzyloxyindolyl]carbonyl-2-isopropyl hydrazide (IH-3), that irreversibly inhibits mouse brain type A monoamine oxidase is measured by 5-hydroxytryptamine deamination. The concentration required in vitro to inhibit this isoenzyme is about 7 X 10(-8) mol/l. Other biochemical and pharmacological features of this potential antidepressant are presented.