Effect of neuroleptics on foot-pedal self stimulation from the ventral tegmentum mesencephali in rats and its correlation with cataleptogenic action
Talalaenko, A.N.; Boreĭsha, I.K.; Zin'kovskaia, L.I.
Farmakologiia i Toksikologiia 45(2): 19-22
1982
ISSN/ISBN: 0014-8318 PMID: 6122595 Document Number: 188633
Experiments on rats have shown that droperidol, fluorophenazine, haloperidol, triphtazine, aminazin, thioridazin and clozapin are capable to reduce pedal self-stimulation from the ventral tegmen of the midbrain, which is not related to the cataleptogenic action of the neuroleptics or to their effect on the actuating motor mechanisms but is a consequence of the action on the emotional-positive reinforcement system. A significant positive correlation was disclosed between the ability of the neuroleptics given in effective doses to reduce pedal self-stimulation from the ventral tegmen and their cataleptogenic action.