The effect of guanfacine on the background and nociceptive stimulation-induced activity of spinal cord neurons in rats
Ivanov, V.E.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 12-15
1997
ISSN/ISBN: 0869-2092 PMID: 9324388 Document Number: 476733
Guanfacine in analgesic doses of 2.0 and 4.0 mg/kg inhibits the background activity of the spinal cord posterior horn neurons and their responses to nociceptive stimulation of the receptive field in conscious rats. Naloxone (0.1 mg/kg) does not change, whereas prazosin and yohimbine (both on doses of 0.1 mg/kg) remove and partly relieve the depressant effect of guanfacine.
Document emailed within 1 workday
Related Documents
Ignatov, I.D. 1977: Effect of analgesics on the background and evoked activity of neurons of the posterior horn of the spinal cord in intact and spinal cats Farmakologiia i Toksikologiia 40(3): 267-272Nemirovskiĭ, A.I. 1985: Effect of M-cholinomimetics on nociceptive stimulation in the spinal cord Farmakologiia i Toksikologiia 48(5): 36-39
Arushanian, E.B.; Belozertsev, I.A.; Aĭvazov, K.G. 1974: Comparative effect of phenamine and caffeine on the background activity of the cortical sensorimotor neurons and their responses to stimulation of the caudate nucleus Biulleten' Eksperimental'noi Biologii i Meditsiny 78(7): 59-62
Yuan, Y.; Wang, J-Yao.; Yuan, F.; Yu, Y-Hao.; Wang, G-Lin. 2012: Changes of glycogen synthase kinase-3β and its phosphorylation in spinal cord neurons in rats with incisional pain-remifentanil-induced hyperalgesia Zhonghua Yi Xue Za Zhi 92(7): 435-439
Besson, J.M.; Conseiller, C.; Hamann, K.F.; Maillard, M.C.; Aléonard, P. 1971: Modifications of the unit activity of dorsal horn neurons of the spinal cord under the effect of intra-arterial injection of bradykinin at the level of the hindlimb in cats Journal de Physiologie 63(6): 171A-172A
Ide, R.; Fukusaki, M.; Yamaguchi, K.; Matsumoto, M.; Ogata, K.; Sumikawa, K. 1997: Effect of controlled hypotension induced by prostaglandin E1 on evoked spinal cord potential and spinal cord blood flow Masui. Japanese Journal of Anesthesiology 46(10): 1342-1346
Bianchi, A.L. 1971: Localization and study of respiratory medullary neurons. Antidromic starting by spinal cord or vagal stimulation Journal de Physiologie 63(1): 5-40
Dolgikh, V.G.; Reshetniak, V.K. 1989: The effect of electroacupuncture on the neuronal responses of the oral trigeminal nucleus in the cat during nociceptive and non-nociceptive stimulation Biulleten' Eksperimental'noi Biologii i Meditsiny 108(12): 646-648
Mamatov, A.U. 1970: Autoradiographic study of protein synthesis in sensory neurons of the spinal ganglia and motor neurons of the spinal cord Arkhiv Anatomii Gistologii i Embriologii 58(5): 91-99
Fang, C.; Xu, Z.; Yang, M.; Xie, J.; Li, Q. 2016: Effect of Time-Related Administration of Methotrexate on Spinal Cord Injury-Induced Neural Cell Apoptosis in Rats Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 30(4): 466-472
Kruchenko, Z.O. 2009: The effect of D2-receptor blockade on the normal and stress-induced activity of the prefrontal cortex neurons in SHR rats Fiziolohichnyi Zhurnal 55(3): 100-108
Zhukova, N.I. 1971: Change in the cholinesterase activity of motor neurons of the rat spinal cord in experimental thyroidin toxicosis Biulleten' Eksperimental'noi Biologii i Meditsiny 72(8): 100-101
Bogacheva, I.N.; Nikitin, O.A.; Musienko, P.E.; Savokhin, A.A.; Gerasimenko, I.P. 2009: Mechanisms of stepping rhythm formation during epidural spinal cord stimulation in decerebrated and spinal cord transected cats Biofizika 54(3): 529-536
Emeliannikov, D.V.; Shapkova, E.Y.; Moshonkina, T.R.; Gerasimenko, Y.P. 2016: Evaluation of motor neuron excitability in lumbosacral spinal cord: Transcutaneous spinal cord stimulation as compared to H-reflex Fiziologiia Cheloveka 42(3): 32-36
Wygladalska-Jernas, H.; Szczech, J.; Godlewski, A. 1984: Cytophotometry of nucleic acids and morphometry of motor neurons and oligodendroglia in the spinal cord of rats treated with CCNU (lomustine) Journal für Hirnforschung 25(5): 487-492
Turbes, C.C. 1997: Intercostal nerve nerve neuroma (PNS) implantation in spinal cord anastomosis bridging spinal cord transection--enhancement of central neurons (CNS) axonal regeneration Biomedical Sciences Instrumentation 34: 344-350
Xie, G.X.; Han, J.S. 1984: Dynorphin: analgesic effect via kappa receptors in spinal cord of the spinal cords of rats Zhongguo Yao Li Xue Bao 5(4): 231-234
Le, T.L.; Chernositov, A.V. 1982: Effect of testosterone on the background impulse activity of the arcuate nucleus neurons of the hypothalamus Biulleten' Eksperimental'noi Biologii i Meditsiny 94(8): 5-6
Soeda, S. 1988: An experimental study on conductive spinal cord action potentials evoked by direct stimulation of the spinal cord--pathway and source of conductive action potentials in the spinal cord Nihon Seikeigeka Gakkai Zasshi 62(5): 535-549
Khanbabian, M.V.; Khudaberdian, D.N.; Khanbabian, A.M.; Arutiunian, A.G.; Gevorkian, A.P. 2004: Taurine effects on background impulse activity of the internal geniculate body neurons and mesencephalic inferior tubers of white rats Vestnik Otorinolaringologii 4: 15-17