Spontaneous blastogenesis of peripheral blood lymphocytes and of mononuclear cells in the dermal infiltrates of atopic dermatitis
Van Neste, D.; Lachapelle, J.M.; Thomas, P.
Annales de Dermatologie et de Venereologie 109(2): 127-132
1982
ISSN/ISBN: 0151-9638 PMID: 7092062 Document Number: 188059
A negative relationship between levels of spontaneous blastogenesis of mononuclear cell infiltrates of the superficial dermis and of lymphocytes circulating in the peripheral blood has been found in a small group of patients with atopic dermatitis. While lymphocytes extravasate into the interstitial spaces of the skin, they come under the influence of a wide variety of mediators some of which may have significant effects on their cellular function. Subsequently troubled lymphocyte traffic backwards to the circulating blood lymphocyte pool via the lymphatics may be of unexpected importance to understand transient depression of cell mediated immunity in patients with severe atopic skin disease.