Co-stimulatory molecules on peripheral blood mononuclear cells and tissue infiltrating cells of skin wart and in vitro poke weed mitogen stimulation
Phumeesat, P.; Charuwichitratana, S.; Vongsakul, M.
Journal of the Medical Association of Thailand 90(9): 1879-1882
2007
ISSN/ISBN: 0125-2208 PMID: 17957934 Document Number: 2967
Background. Skin wart is a lesion caused by human papilloma viruses (HP Vs) that can infect both male and female. Objective: Quantify the number of CD28(+), CD86(+), CD152(+) and gamma delta(+) in peripheral blood mononuclear cells (PBMCs) of subjects with skin wart. Identify CD86(+) and gamma delta(+) cells in skin wart cryosections. Material and Method. Sixteen subjects with skin warts on face, hand, finger, knee, foot or plantar both male and female, aged between 19-59 years-old, were recruited from Ramathibodi Hospital, Mahidol University, Bangkok Results: CD86 and CD152, on peripheral blood mononuclear cells (PBMCs) of subjects with skin wart are significantly lower compared to controls. Tissue cryosection staining for CD86(+) and gamma delta(+) cells showed no difference among subjects with skin wart and control. Proliferative response to poke weed mitogen of subjects with skin wart is significantly lower than control subjects. Conclusion: There was no difference in the number of subjects positive for CD28 and CD86 cell between normal and skin wart subject, but an increase in skin wart subjects with gamma delta(+) cells.
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