Alterations of sleep stage pattern in human beings and hang-over effects under the influence of estazolam/2nd Comm.: Studies on the hang-over effect in psycho-physiological performance
Müller, K.W.; Müller-Limmroth, W.; Strasser, H.
Arzneimittel-Forschung 32(4): 456-460
1982
ISSN/ISBN: 0004-4172 PMID: 6125155 Document Number: 187485
10 healthy male and female subjects spent 7 nights both with a quiet surrounding and defined noise of subsonic jet fly-overs in a sleep laboratory. During the last 4 nights they were medicated in a double-blind cross-over test design with the benzodiazepine 8-chloro-6-phenyl-4H-s-triazolo (4,3-a)-(1,4)benzodiazepine (estazolam, BAY k 4200) at a dosage of 2 mg and placebo. On each following morning they passed a tracking test and an apparative mental arithmetic calculation test in order to evaluate a potential hangover. Simultaneously heart rate was registered continuously. The results were as follows: About 10 h after medication significant hang-over effects of estazolam in psycho-physiological performance could still be seen. Statistically significant differences between the conditions with estazolam and placebo in the range of 5 to 15% were found. Hang-over is not restricted to tracking and mental performance but can also be seen in slightly lowered heart rate.