Cyclic AMP and cyclic GMP in the implantation site of the rat
Vilar-Rojas, C.; Castro-Osuna, G.; Hicks, J.J.
International Journal of Fertility 27(1): 56-59
1982
ISSN/ISBN: 0020-725X PMID: 6122659 Document Number: 187461
Endometrial differentiation of the implantation site (IS) is regulated by hormonal and local influences (egg). To better understand the possible participation of cyclic nucleotides in this process, cAMP and cGMP were measured by radioimmunoassay in Is of the rat on day 6 of pregnancy. IS showed an increase of both nucleotides (3.54 and 0.57 pmol/mg DNA) when compared to the remaining endometrium (NIS) (2.70 and 0.30). The cAMP/cGMP ratio did not change significantly. An increase in the proteins/mg DNA ratio (12.04 in IS vs. 10.63 in NIS) and in the hydration of IS were also found. Apparently, together, these 2 nucleotides function as a monodirectional system in which they act cooperatively as positive effectors of different sequential steps in the overall process of implantation.