Determination of cyclic AMP and cyclic GMP in psoriatic epidermis and dermis
Yang, X.Q.; Wang, G.C.
Chinese Medical Journal 100(3): 216-218
1987
ISSN/ISBN: 0366-6999 PMID: 3040341 Document Number: 291739
This article reports the cyclic AMP and cyclic GMP content of psoriatic epidermis and dermis and compares them with those of normal human skin. Cyclic AMP content of involved and uninvolved epidermis of psoriatic patients were found to be significantly decreased by 41% and 46% respectively (DNA data basis) as compared with normal human skin. But cyclic AMP content of psoriatic dermis was increased by 103% (wet weight), as compared to uninvolved and normal human dermis. Cyclic GMP content of psoriatic epidermis was significantly increased by 124% and 150% (wet weight) as compared with uninvolved and normal human epidermis. These changes may play an important role in causing psoriatic lesions.