Rapid determination of valproic acid using instantaneous silylation
Lacroix, C.; Levert, P.; Goulle, J.P.
Annales de Biologie Clinique 40(6): 681-683
1982
ISSN/ISBN: 0003-3898 PMID: 6819791 Document Number: 185629
We propose a technique for measuring valproic acid using gas phase chromatography with a OV1 column, classically used for steroid assays. The valproic acid is extracted directly from the plasma by either from a small test sample (200 microliters). The silylation is performed instantaneously at the level of the injector. The accuracy and precision of the method are excellent; there is no interference with other anti-convulsants. The technique is simple, very rapid and not expensive; it should find a wide application in routine practice.