Metabolic interaction of valproic acid
Borchert, H.H.; Schuster, S.; Pfeifer, S.
Die Pharmazie 34(5-6): 313-314
1980
ISSN/ISBN: 0031-7144 PMID: 6774345 Document Number: 166357
Valproic acid produces a marked competitive inhibition of the aminophenazone N-demethylation and the codeine phosphate O-demethylation by 9000 g-supernatant of rat liver homogenates, but it exerts virtually no effect on the aniline hydroxylation and the p-nitrophenol glucuronidation which are slightly inhibited only if its tenfold amount is allowed to react on the substrate.