Do cytoprotective prostaglandins act as mild irritants?
Guslandi, M.
Methods and Findings in Experimental and Clinical Pharmacology 4(5): 317-320
1982
ISSN/ISBN: 0379-0355 PMID: 7121138 Document Number: 185369
Of the various mechanisms proposed to explain the cytoprotective properties of prostaglandins, mucus discharge seems the most probable. Mild irritants capable of eliciting mucus release have also been shown to exert cytoprotection. It is suggested that prostaglandins act as mild irritants of the mucosa and that cytoprotection is a mucosal reaction to mild irritation, through stimulation of mucus discharge.