The genetics of the hyperlipidemias and coronary artery disease
Berg, K.
Progress in Clinical and Biological Research 103 Pt B: 111-125
1982
ISSN/ISBN: 0361-7742 PMID: 7163216 Document Number: 184691
The body of evidence incriminating genetic factors in the etiology of CHD includes familial clustering of cases, with or without major hyperlipidemia; genetic influence on serum lipids levels in the general population; effect of genes belonging to normal polymorphisms on serum lipid levels and their variability; atherogenic effect of the genetically determined Lp(a) lipoprotein; and genetic influence on HDL apoproteins. Recent findings concerning the inherited apoE variation and genetic control of LDL cell membrane receptor activity in the general population are potentially of considerable interest. An improved understanding of the interaction between the products of "susceptibility genes" and environmental/dietary factors is important for attempts to prevent or delay the manifestations of atherosclerosis.