Karyotype analysis during development of chronic myelocytic leukemia
Palka, G.; Santi, P.; D'Antuono, A.; Bartoli, S.; Mazzotti, G.; Maraldi, N.M.; Manzoli, F.A.
Bollettino della Societa Italiana di Biologia Sperimentale 57(1): 33-39
1981
ISSN/ISBN: 0037-8771 PMID: 6941789 Document Number: 182477
We report cytogenetic data concerning 9 patients with chronica granulocytic leukemia and eosinophilia at the onset and during the chronic phase of the disease before the blastic crisis. The cariotype analises in the intermediate phases allowed to determine the first changes which could be involved in the evolutionary events of the disease up to the moment in which the typical markers of the blastic crisis can be found.