The application of buprenorphine in balanced anesthesia
Hanaoka, K.; Kugimiya, T.; Ogawa, K.; Fuke, N.; Tagami, M.; Fujisawa, M.; Yoshikawa, H.; Tachibana, N.; Inada, Y.; Yamamura, H.
Masui. Japanese Journal of Anesthesiology 30(10): 1034-1040
1981
ISSN/ISBN: 0021-4892 PMID: 7328728 Document Number: 182215
The application of buprenorphine (an agonistic-antagonism analgesic) in balanced anesthesia was investigated in 104 patients undergoing surgical operation. Premedication was performed with i.m. atropine and hydroxyzine chloride 1 h before the induction of anesthesia. Buprenorphine was i.v. administered 5 min before the induction of the anesthesia with sodium thiopental and the intubation with S.C. C., The anesthesia was maintained by nitrous oxide and oxygen, and curare was used as a muscle relaxant when needed. The doses of buprenorphine employed in this study were 4, 6, 8 and 10 .mu.g/kg and no further doses of buprenorphine were given. In some patients the dose of 4 .mu.g/kg was ineffective and 10 .mu.g/kg excessive, so that 6-8 .mu.g/kg of buprenorphine was considered appropriate for the supplement to the anesthesia. Hemodynamics during the anesthesia was stable. The recovery from the anesthesia was rapid while the analgesic effect lasted long after the operation. There were no notable side effects. From these results buprenorphine was considered to be useful in balanced anesthesia.