Convulsant action of the diguanide derivatives hirudonine, arcaine and audouine
Mori, A.; Hiramatsu, M.; Numoto, A.; Robin, Y.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 175(6): 755-760
1981
ISSN/ISBN: 0037-9026 PMID: 6459819 Document Number: 182110
We applied topically hirudonine (0.17 M), arcaïne (0.1 M) and audouine (0.22 M) on the sensory motor cortex area of the cerebral cortex of rabbit, and found that hirudonine and audouine could induce high voltage multiple spike discharges, i.e. burst, after a few minutes latent period. We found also that arcaïne could induce high voltage spike activity, but could not induce bursting activity.