Antithrombotic effect of sodium ferulate in rats
Xu, L.N.; Ouyang, R.
Zhongguo Yao Li Xue Bao 2(1): 35-37
1981
ISSN/ISBN: 0253-9756 PMID: 6461198 Document Number: 181951
Male rats weighing > 350 g were used. A carotid-jugular extracorporeal shunt was made. A length of silk thread was placed in the shunt. Fifteen minutes after the restoration of blood flow in the shunt, the wet weight of thrombus developed on the thread was measured. The thrombus weight was significantly reduced when sodium ferulate was given 0.3 g/kg i.v. The thrombus weight of the control group was 22.1 .+-. 2.9 mg; that of the medicated group was 11.3 .+-. 1.4 mg. The inhibitory rate was 50%. The antithrombotic effect lasted > 1 h. Sodium ferulate may be of value in the treatment of thromboembolic diseases.