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Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL

Yu, H.; Hong, J.; Wu, D.

Zhongguo Zhong Yao Za Zhi 24(6): 365-366; 384

1999

ISSN/ISBN: 1001-5302
PMID: 12212033
Document Number: 500373
To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC). Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis. SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner. SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.

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