Intestinal response to glucose in experimental cholera in malnourished, adult and growing rats
Mansour, A.B.; Desjeux, J.F.
Archives Francaises de Pediatrie 38(Suppl 1): 823-828
1981
ISSN/ISBN: 0003-9764 PMID: 6800333 Document Number: 181285
We examined the influence of malnutrition on intestinal response to glucose in experimental cholera. Water, electrolytes, and glucose fluxes were directly measured, in isolated ligated loops of rat jejunum. Intestinal loops were filled with Ringer added with either mannitol (30 mM), glucose (30 mM), cholera toxin (TC), or a combination of these three components. The results are as follows: 1. Malnutrition has an effect on basal absorption rate, intestinal response to TC and also to glucose. 2. The secretory effect of cholera toxin is altered by the type of malnutrition, the animal's age and the presence of cholera toxin. 3-0 methyl-glucose, a non-metabolised glucose analogue, has essentially the effect of glucose. The effects produced on water fluxes are also found for Na, K, Cl, HCO3 and glucose fluxes. The relationships between water, glucose, and Na fluxes are not influenced by the different experimental conditions. These results indicate that the intestinal response to glucose in experimental cholera is strongly dependent on the type of malnutrition, the animal's age and the presence of cholera toxin.