Comparison of arrhythmic effects of aconitine and its 5 analogues
Dong, Y.L.; Chen, W.Z.; Ding, G.S.
Zhongguo Yao Li Xue Bao 2(3): 173-176
1981
ISSN/ISBN: 0253-9756 PMID: 6462007 Document Number: 181161
The acute i.p. LD50 in mice of mesaconitine (MA), aconitine (AC), beiwutine (BA), hypaconitine (HA), 3-acetylaconitine (AA) and deoxyaconitine (DA) were 0.22, 0.27, 0.42, 0.50, 1.01 and 1.90 mg/kg, respectively. These 6 drugs i.v. induced arrhythmias in anesthetized rats. The potencies of these drugs (1/14 of LD50) were BA > MA > AC = AA > HA > DA. BA and DA yielded a modest, while other drugs produced a severe, respiratory depression. BA 10 .mu.g/kg i.v. caused an arrhythmia in anesthetized rats, yet the drop in blood pressure was not marked. BA in aqueous solution was more stable than AC. Evidently BA is superior to AC for producing arrhythmia models for screening of drugs.