Certain biochemical parameters of blood serum in patients with liver metastases of lymphogranulomatosis
Pashintseva, L.P.; Demina, E.A.; Pirogova, N.A.
Terapevticheskii Arkhiv 53(9): 62-65
1981
ISSN/ISBN: 0040-3660 PMID: 7302862 Document Number: 181017
The content of total protein, albumin, .alpha.2-globulin, fibrinogen, haptoglobin, ceruloplasmin, bilirubin, the activity of aminotransferases of aspartic acid and alanine, lactate dehydrogenase, alkaline phosphatase and its isozymes, and the characteristics of the bromosulfalein test were studied in the serum of 173 lymphogranulomatosis patients and 36 normal adult subjects. Biochemical characteristics of serum from patients with morphologically verified liver lymphogranulomatosis were compared to the respective characteristics of patients without this disease and to those of patients with nonspecific changes in the liver (control subgroups). In patients with liver lymphogranulomatosis, the activity of serum alkaline phosphatase significantly increased as compared to controls. High values of alkaline phosphatase activity (> 4-fold normal) may be used for diagnosis of the specific liver affection. Normal or moderately elevated activity of serum alkaline phosphatase does not exclude the presence of specific liver disease. Increased activity of alkaline phosphatase was accompanied in 85% of cases with the appearance of the .alpha.1-fraction of that enzyme.