Genetic screening for mental retardation in Michigan
Thoene, J.; Higgins, J.; Krieger, I.; Schmickel, R.; Weiss, L.
American Journal of Mental Deficiency 85(4): 335-340
1981
ISSN/ISBN: 0002-9351 PMID: 7457497 Document Number: 180985
The Michigan Department of Mental Health established a genetic screening laboratory in 1977 to provide diagnostic information on retarded patients. Of 727 patients screened during a 2 yr period, a genetic diagnosis was established for 121 moderately to severely retarded patients. Genetic counseling was provided for 40% of their parents. A wide varieity of chromosomal abnormalities, inborn errors of metabolism and dysmorphic syndromes was discovered, including 16 instances of previously unknown familial conditions. This program has demonstrated a cost-effective method for determining genetic etiology in mental retardation and, in some instances, has led to prevention of mental retardation.