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The clinico-genetic aspects of mental retardation related to the fragile-X chromosome

Viekhova, N.V.; Demydova, I.A.; Bychkova, H.M.; Vorsanova, S.H.; Buzhiievs'ka, T.I.

Tsitologiia i Genetika 26(6): 64-71

1992

ISSN/ISBN: 0564-3783
PMID: 1292164
Document Number: 404417
This review deals with main problems of syndrome of X-fragile chromosome. The history of discovery and subsequent study of diseases as well as methods of examination, main clinical symptoms, methods of treatment and prophylaxis have been described. Some hypotheses, explaining complicated mechanism of fra-X syndrome inheritance are discussed. The recent achievements of molecular and genetic investigations of mental backwardness, associated with X-fragile chromosome are included in review.

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