Emotionally positive reactions in the process of development of diazepam dependence
Zvartau, E.E.
Farmakologiia i Toksikologiia 44(1): 21-25
1981
ISSN/ISBN: 0014-8318 PMID: 7196342 Document Number: 179707
Rats with lateral hypothalamic electrodes were treated with diazepam in doses of 10--20 mg/kd during 10 days. Part of the animals showed tolerance to the inhibitory effect of the drug. Within the drug administration period depression of the self-stimulation response was observed under 24-hour abstinence. After diazepam withdrawal two forms of abstinent changes were noted--inhibition and facilitation. The effects of diazepam were modulated by opiate receptors' blockade with naloxon.
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