Regulation of intracellular protein degradation by insulin and growth factors
Ballard, F.J.; Nield, M.K.; Francis, G.L.; Knowles, S.E.
Acta Biologica et Medica Germanica 40(10-11): 1293-1300
1981
ISSN/ISBN: 0001-5318 PMID: 6282020 Document Number: 178935
Protein breakdown in many cell lines is inhibited by growth factors. The response is specific, rapid and additive only at suboptimal concentrations. Transformed cells are typically more sensitive to growth factors than nontransformed cells while the effectiveness of growth factors in human fibroblasts is diminished with senescence. Bovine colostrum has been shown to be an extremely rich source of growth factors as compared to serum.
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