Protein degradation in vivo and its regulation
Schimke, R.T.
Circulation Research 38(5 Suppl 1: I131-I137
1976
ISSN/ISBN: 0009-7330 PMID: 1269088 Document Number: 107277
Protein degradation in mammalian cells may be regulated by size of the polypeptide subunit, susceptibility to degradation by proteases, alteration by mutational changes, and interaction with various ligands, including other proteins, lipids, cofactors, or metabolic intermediates. The pathway of degradation is not defined but appears to involve both lysosomal and nonlysosomal proteases.
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