Top Abstract Purchase Related
Home
>
Node
>
Subnode

Endogenous degradation of DNA and chromatin in rat liver nuclei after in vivo treatment with cis- and trans-diamminedichloroplatinum (II)

Ganeva, R.; Kokileva, L.

Cytobios 62: 250-251

1990

ISSN/ISBN: 0011-4529
PMID: 2171880
Document Number: 356429
Rat liver nuclei were isolated from untreated and treated animals in vivo with cis- and trans-diamminedichloroplatinum (II). Comparative gel electrophoresis of rat liver DNA extracted from incubated nuclei revealed that endogenous degradation of DNA was significantly slower in the nuclei isolated from rats treated with the platinum complexes. The decrease in the rate of DNA degradation was more rapid with trans- than with cis-diamminedichloroplatinum (II). This in vivo effect of platinum complexes does not correlate with their antitumour activity.

Document emailed within 1 workday
Secure & encrypted payments

Khodarev, N.N.; Votrin, I.I. 1982: Functional heterogeneity of chromatin fractions isolated by limited hydrolysis of endogenous Ca 2+, Mg 2+ -dependent endonuclease of rat liver nuclei Biulleten' Eksperimental'noi Biologii i Meditsiny 94(11): 37-39
Bhargava, P.; Mayalagu, S. 1990: Magnesium induced activation of endogenous nucleases from isolated yeast nuclei: liberation of chromatin fragments of mono- and oligo- nucleosome size Biochemistry International 20(6): 1041-1048
Kulagina, T.P.; Kolomiĭtseva, I.K.; Obol'nikova, E.A.; Samokhvalov, G.I.; Kuzin, A.M. 1992: Effects of ubiquinone-9 on lipids of nuclei and chromatin of the rat liver under continuous irradiation Biulleten' Eksperimental'noi Biologii i Meditsiny 113(3): 253-254
Kliasheva, R.I. 1993: Ultrastructure of chromatin in nuclei of hepatocytes of regenerating guinea pig liver after administration of vitamin B12 Biulleten' Eksperimental'noi Biologii i Meditsiny 115(5): 544-546
Leĭkina, E.M.; Romanova, L.K.; Spitkovskiĭ, D.M. 1973: Physico-chemical properties of chromatin fractions from the nuclei of normal and regenerating rat liver cells Biulleten' Eksperimental'noi Biologii i Meditsiny 74(2): 38-40
Lobanenkov, V.V.; Mironov, N.M.; Shapot, V.S. 1982: Proteins and the functional properties of the chromatin fractions from the nuclei of the normal liver and of experimental hepatomas Biulleten' Eksperimental'noi Biologii i Meditsiny 93(5): 60-63
Goureau-Counis, M.F.; Fichot, O.; Raulin, J.; De Recondo, A.M. 1974: Phospholipid configuration and template capacity of liver nuclei and purified chromatin in presence or absence of hepatic DNA polymerase Physiological Chemistry and Physics 6(5): 379-392
Gubskiĭ, I.I.; Levitskiĭ, E.L.; Gol'dshteĭn, N.B.; Litoshenko, A.I. 1989: Lipid peroxidation and the endogenous DNA polymerase activity of fractions of isolated liver chromatin in rats Biulleten' Eksperimental'noi Biologii i Meditsiny 107(3): 296-298
Murray, D.; Jenkins, W.T.; Meyn, R.E. 1985: Kinetics of DNA cross-linking in normal and neoplastic mouse tissues following treatment with cis-diamminedichloroplatinum(II) in vivo Cancer Research 45(12 Part 1): 6446-6452
Jorgensen, E.C.; Dietrich, S.W.; Koerner, D.; Surks, M.I.; Oppenheimer, J.H. 1975: Thyroid hormones: comparative structural requirements for activity in vivo and for binding to rat liver nuclei Proceedings of the Western Pharmacology Society 18: 389-392
Baxter, C.S.; Byvoet, P. 1974: Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase Cancer Research 34(6): 1424-1428
Demin, S.Iu. 1999: Structure of chromatin and chromosomes in preparations of interphase nucleus derivatives, prepared by removal of the nucleuar envelopes. II. Structure of chromatin and associations of chromosomes in stretched amembranous nuclei and mitotic figures Tsitologiia 41(1): 66-86
Rauko, P.; Hrubisko, M.; Hanusovská, E. 1990: Electrophoretic analysis of DNA modifications induced by cis- and trans-diamminedichloroplatinum (II) during heat-denaturation of conformation isomers of pBR322 DNA Neoplasma 37(2): 131-138
Blasko, M.; Kvietiková, I.; Plesková, I.; Chalupa, I.; Kuliffay, P.; Siracký, J. 1987: Cytogenetic changes of human peripheral blood lymphocytes in vitro after exposure to cis-DDP (cis-diamminedichloroplatinum II) and oxo-Pt (cis-diamminedichloro-trans-dihydroxyplatinum IV) Neoplasma 34(2): 235-238
Zwelling, L.A.; Kohn, K.W.; Ross, W.E.; Ewig, R.A.; Anderson, T. 1978: Kinetics of formation and disappearance of a DNA cross-linking effect in mouse leukemia L1210 cells treated with cis- and trans-diamminedichloroplatinum(II) Cancer Research 38(6): 1762-1768
Jin, S-min.; Liu, H-chen. 2004: Gender-related differences in metabolism of the enantiomers of trans tramadol and trans O-demethyltramadol in rat liver microsomes Yao Xue Xue Bao 39(8): 581-585
Manteĭfel', V.M.; Romanenko, E.B.; Babadzhanian, D.P.; Zelenin, A.V.; Vaniushin, B.F. 1988: Electron microscope study of chromatin in nuclei of rat hepatocytes during age-related changes in the genome Molekuliarnaia Biologiia 22(4): 1087-1096
Seeber, S.; Osieka, R.; Schmidt, C.G.; Achterrath, W.; Crooke, S.T. 1982: In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II) Cancer Research 42(11): 4719-4725
Beach, D.J.; Sunderman, F. 1970: Nickel carbonyl inhibition of RNA synthesis by a chromatin-RNA polymerase complex from hepatic nuclei Cancer Research 30(1): 48-50
Almagor, M.; Cole, R.D. 1989: Differential scanning calorimetry of nuclei as a test for the effects of anticancer drugs on human chromatin Cancer Research 49(20): 5561-5566