Modifications of disulfiram and its metabolites in blood in alcoholic hepatopathy
Chalas, J.; Labayle, D.; Lindenbaum, A.; Cluet, J.L.; Godin, J.; Leluc, R.; Etienne, J.P.
Pathologie-Biologie 29(3): 163-168
1981
ISSN/ISBN: 0369-8114 PMID: 6264368 Document Number: 178903
In cirrhotic, steatosic and healthy subjects, the authors studied the metabolism of disulfiram (TETD) administrated orally (500 mg) 3 consecutive days. Carbon disulfide (CS2) and the whole TETD, diethyl dithiocarbamate (DDC) disulfides, were determined by a gas chromatographic method. The evolution of metabolites is similar in steatosic and healthy subjects. In cirrhotics the CS2, DDC and disulfides level increase within the 3 days. This phenomenon may be related with hepatic toxicity of TETD and with the persistence of disulfiram-alcohol reaction. The authors suggest to use low doses of disulfiram in cirrhotic.