The effect of tienilic acid on Na+ and K+ transport in human red cells
Cusi, D.; Garay, R.
Molecular Pharmacology 19(3): 438-443
1981
ISSN/ISBN: 0026-895X PMID: 6267447 Document Number: 178498
Tienilic acid inhibits erythrocyte Na+,K+ cotransport to a lesser extent than does furosemide. This property seems to be proportional to its diuretic effects. Under conditions in which the erythrocytes have all of their saturable Na+ and K+ transport systems blocked, the addition of tienilic acid induces an increase in K+ permeability. This effect shows saturation kinetics with the increase in the internal K+ concentration and could not be inhibited by ethylene glycol bis(.beta.-aminoethyl ether)-N,N,N',N'-tetraacetic acid, quinine, carbocyanine or tetraethylammonium. The main effects of tienilic acid on transmembrane cation transport may be the opening of transient or permanent K+ channels.