Hydrophobic parameters in homologous series of psychopharmaceuticals
Barbato, F.; Cappello, B.; Recanatini, M.; Silipo, C.; Vittoria, A.
Bollettino della Societa Italiana di Biologia Sperimentale 57(17): 1800-1806
1981
ISSN/ISBN: 0037-8771 PMID: 7306420 Document Number: 177270
The 1-octanol/water partition coefficients of sets of 1,4-benzodiazepine and phenothiazine derivatives are determined. The values of the hydrophobic parameters obtained by shake-flask procedure are correlated to the corresponding HPLC retention times. The existence of linear correlations between the two experimentally determined parameters clearly show that chromatographic indices model excellently the shake-flask parameters.