Estrogen-dependent changes in DNA synthesis in the rat adenohypophyseal cells

Komolov, I.S.; Peres-Arse, K.A.; Fedotov, V.P.

Problemy Endokrinologii 27(3): 56-61

1981


ISSN/ISBN: 0375-9660
PMID: 7291140
Document Number: 176800
Estradiol benzoate injection to intact and ovariectomized rats during four days was accompanied by a marked increase in 3H-thymidine incorporation rate in DNA of incubated adenohypophyses. 17 beta-estradiol addition to the culture medium selectively augmented the lactotropic cell percentage in the primary monolayer culture, undergoing DNA synthesis stage. Possible pathways of mediated and direct estrogen effects on DNA synthesis by adenohypophyseal cells are discussed.

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