Penicillamine and the SLE syndrome
Walshe, J.M.
Journal of Rheumatology. Suppl 7: 155-160
1981
ISSN/ISBN: 0380-0903 PMID: 6939878 Document Number: 176759
Penicillamine-induced systemic lupus erythematosus (SLE) and penicillamine-immune complex nephritis are histologically and serologically distinct. One hundred and twenty patients with Wilson's disease treated with penicillamine have been analyzed. Eight developed the serologic changes of SLE; in 4, it was necessary to discontinue treatment. In addition, 6 patients developed immune complex nephritis, which necessitated discontinuing treatment. All but 1 have since been managed on triethylene tetramine 2HCl (Trien).