Ranitidine: a pilot study in Japan
Takemoto, T.; Okazaki, Y.; Okita, K.; Namiki, M.; Ishikawa, M.; Oshiba, S.; Kurokawa, K.
Scandinavian Journal of Gastroenterology. Suppl 69: 125-128
1981
ISSN/ISBN: 0085-5928 PMID: 6119776 Document Number: 176598
Twenty-four patients with gastric ulcer and 18 with duodenal ulcer diagnosed by endoscopy were treated with ranitidine, 300 mg day-1, for 8 consecutive weeks, or until the ulcer was found endoscopically healed. Of the 24 with gastric ulcer, 50% were healed within 4 weeks, and 83% within 8 weeks. Of 18 cases with duodenal ulcer, 50% were healed within 2 weeks and 94% within 4 weeks. Therapeutic effect of ranitidine was statistically significant compared with placebo. Side effects due to ranitidine administration were few and consisted of a rash in one case and slight increase of transaminase in a few patients.