The recurrence of duodenal ulcer in patients undergoing treatment with ranitidine and placebo. a multicenter study
Villalobos, J.J.; Nava, A.A.; Elizondo, J.; Gallo, S.; Guerrero, C.; Vargas, F.; Barrera, A.; Centeno, F.; Marín, E.; Peña, F.
Revista de Gastroenterologia de Mexico 56(2): 65-69
1991
ISSN/ISBN: 0375-0906 PMID: 1947617 Document Number: 377743
This randomised, double-blind multicenter study was conducted in order to evaluate the long-term effect (one year) of 150 mg ranitidine vs placebo in 51 patients with healed duodenal ulcer. Seventeen patients had ulcer recurrence at the end of follow-up, one among the 24 patients that received ranitidine and 16 among the 27 patients that received placebo (p = 0.00009). No side effects was detected. Our results support the usefulness of a one-year maintenance therapy with 150 mg ranitidine.