Randomised double blind placebo controlled clinical trial of sucralfate and ranitidine in chronic duodenal ulcer
Nair, K.V.; Ramachandran, T.M.; Thomas, V.; Rajindranath, T.
Journal of the Association of Physicians of India 38(3): 211-212
1990
ISSN/ISBN: 0004-5772 PMID: 2202705 Document Number: 363265
A double blind, randomised, placebo controlled clinical trial was carried out in endoscopically proved chronic duodenal ulcer patients to compare the efficacy of sucralfate and ranitidine. Sucralfate 1 g four times daily and ranitidine 150 mg twice daily were found to be equally effective in inducing ulcer healing (73.1% and 82.1% respectively) during the 6-week treatment period. The rate of recurrence of the ulcer within six months after the initial treatment (84.2% and 82.6%) was also comparable in the sucralfate and ranitidine groups. Sucralfate and ranitidine are equally effective in ulcer healing and prevention of ulcer relapse.